Serum 25(OH)D was measured by radioimmunoassay(RIA) (kits manufactured by Biosource Europe SA, Belgium). All results were presented as Mean±SD, or medians of non-normally distributed.Ģ4% of the participants were Vitamin D deficient, insulin, Ca(Calcium), P(Phosphorous) and ALP(Alkaline Phosphatase). Resultsġ00 participants including 70 women (70%) and 30 men (30%) took part in the study. The results were analyzed by descriptive tests, and a comparison between variables were made using paired T-tests or Wilcoxon tests, as appropriate. Patients received 50,000 unit of vitamin D 3 orally per week for eight weeks, Statistical analysis was made using SPSS17. All measurements were performed at the beginning and the end of the study. Serum insulin and, 25(OH)D concentration, and HOMA-IR was calculated. Participants were assessed for clinical and biochemistry.

Through a before-after study, 100 patients with T2DM, 30–70 years old, were recruited from an Arak diabetes clinic as consecutive attenders. This study evaluates the effects of vitamin D supplementation on insulin resistance in T2DM. Different studies provide evidence that vitamin D may play a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity. Over the past decade, numerous non-skeletal diseases have been reported to be associated with vitamin D deficiency including type2 diabetes mellitus (T2DM).

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